Possible mechanism of parenchymal destruction on the analogy of image analysis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461156
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kyoto University
• Principal Investigator: Shigeo Muro 京都大学, 医学(系)研究科(研究院), 講師 (60344454)
• Co-Investigator(Kenkyū-buntansha): SATO ATSUYASU 京都大学, 医学研究科, 特定病院助教 (30706677)
• Co-Investigator(Renkei-kenkyūsha): NAKAMURA TOMOYUKI 関西医科大学, 医学研究科, 教授 (20362527)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 呼吸器内科 / 肺気腫 / 細胞外マトリクス / 炎症 / 画像解析

Outline of Final Research Achievements

In our COPD prospective observational clinical study, we recruited 82 COPD subjects. Preliminary analysis showed that humoral immunity influence the frequency of COPD exacerbations. The observation period will complete at the end of June 2016, and we will finalize the data and analyze the final data. At the same time, we established the model mouse of the pulmonary emphysema by giving a small amount of proteolytic enzyme in the respiratory tract. We tried to prevent emphysema development by adding elastic fiber synthetic related protein in the lung, however, we could not find strong evidence that our method could prevent emphysema in the whole lung. However, the pathology showed that some destroyed lung field were repaired by new lung cells. We will continue to study this repair process and try to establish new regenerative method in COPD treatment.

Free Research Field

呼吸器内科