Proteomic analysis and genotyping of nontuberculosis mycobacteria to investigate effects of traditional Chinese medicines against pathogenesis

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461159
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Shimane University
• Principal Investigator: SANO Chiaki 島根大学, 医学部, 准教授 (70325059)
• Research Collaborator: TANINO Ryosuke 島根大学, 医学部, 研究員
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 非結核性抗酸菌 / 漢方薬 / 免疫補助療法 / マウスモデル / ジェノタイプ

Outline of Final Research Achievements

Nontuberculosis mycobacterial infections are characterized by the ineffectiveness of antimycobacterial drugs. The disease results in immuno-suppression and infection with dormant types of mycobacteria and, to date, available chemotherapy regimens are limited. The aim of this study was to investigate useful traditional Chinese medicines for adjunctive chemotherapy against refractory mycobacteriosis. First, we investigated whether the drug susceptibility profile of the Mycobacterium avium complex (MAC) is associated with the genotype. Next, we established a human nodular bronchiectatic MAC lung disease model by novel intrapulmonary injection techniques. The oral administration of “Mao-To” decreased the expression of Th2-related cytokines in novel mouse models.

Free Research Field

細菌学