2016 Fiscal Year Final Research Report
The role of sphingosine 1-phosphate signaling in hypersensitivity pneumonitis
Project/Area Number |
25461182
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Keywords | 過敏性肺炎 / スフィンゴシン1-リン酸 / フィンゴリモド塩酸塩 |
Outline of Final Research Achievements |
In hypersensitivity pneumonitis, the influx of lymphocytes induce inflammation in the lung. In this study, we used the hypersensitivity pneumonitis mouse model that inhaled PDE (pigeon dropping extracts)and investigated the role of sphingosine 1-phosphate (S1P) signaling. FTY720 (Fingolimod) is a S1P receptor modulator that inhibits lymphocyte emigration from lymphoid organs. The administration of FTY720 inhibited the influx of lymphocytes and neutrophils into the lung, and the mRNA expression of IL-17A in bronchoalveolar lavage cells. But FTY720 did not affect the fibrosis of the lung tissues. Furthermore, the SphK inhibitor did not affect the lung fibrosis induced by PDE inhalations.
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Free Research Field |
間質性肺炎
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