Development of novel diagnosis method for renal desease using metabolome analysis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461217
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Fujita Health University (2014-2015); Nagoya University (2013)
• Principal Investigator: OZAKI Takenori 藤田保健衛生大学, 医学部, 講師 (10452195)
• Co-Investigator(Kenkyū-buntansha): MATSUO Seiichi 名古屋大学, 大学院医学系研究科, 教授 (70190410) ; MARUYAMA Shoichi 名古屋大学, 大学院医学系研究科, 准教授 (10362253) ; AKIYAMA Shinichi 名古屋大学, 大学院医学系研究科, 特任講師 (20500010) ; HIRAYAMA Akiyoshi 慶應義塾大学, 大学院政策メディア研究科, 特任助教 (00572405)
• Co-Investigator(Renkei-kenkyūsha): SOGA Tomoyoshi 慶應義塾大学, 環境情報学部, 教授 (60338217)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: メタボローム / 腎疾患 / バイオマーカー

Outline of Final Research Achievements

We performed matobolome analyses using the urine specimen of 274 nephrotic syndrome patients with top 7 biopsy proven pathological diagnoses (minimal change nephrotic syndrome, membranous nephropathy, diabetic nephropathy, focal segmental glomerulosclerosis, amyloid nephropathy, lupus nephritis, and lgA nephropathy). Metabolites which can predict a diagnosis were obtained. We then performed validation study using other 120 cases, and got similar results.
We also performed metabolome analyses using the plasma of 173 cases from patients who underwent the inulin clearance test, and I got the metabolites which are positively or negatively associated with decreased GFR.

Free Research Field

腎臓内科学