2015 Fiscal Year Final Research Report
Role of Indolethylamine Nmethyltransferase in chronic kidney disease
| Project/Area Number |
25461218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Uzu Takashi 滋賀医科大学, 医学部, 准教授 (20422884)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 尿細管 / 糖尿病性腎症 |
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| Outline of Final Research Achievements |
We examined the role of Indolethylamine N－methyltransferase, a new target for the tubular damage, in chronic kidney disease. In the proximal culture cells, cell damages were reduced by over-expression of Inmt. On the other hand, those damages were enhanced by the inhibition of Immt by using specific siRNA. However, we found no differences between wild and Inmt KO mice in the chronic kidney diseases models.
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| Free Research Field |
腎臓病学
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