2015 Fiscal Year Final Research Report
Fatty acid composition and diabetic nephropathy
| Project/Area Number |
25461219
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
UZU Takashi 滋賀医科大学, 医学部, 准教授 (20422884)
MAEDA Shiro 独立行政法人理化学研究所, 統合生命医科学研究センター, チームリーダー (50314159)
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| Research Collaborator |
KUME Shinji 滋賀医科大学, 医学部, 特任助教 (00452235)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 糖尿病性腎症 / 脂肪酸 / 飽和脂肪酸 / 不飽和脂肪酸 / 蛋白尿 |
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| Outline of Final Research Achievements |
This study was designed to identify the role of free fatty acid (FFA) composition in the progression of diabetic nephropathy, a leading cause of renal failure in Japan. Omega-3 unsaturated fatty acid prevented rapid renal function decline without affecting levels of proteinuria in the diabetic patients with overt proteinuria. SCD1 is a rate limiting enzyme converting saturated FFAs to monounsaturated FFAs. SCD1 overexpresion in the cultured proximal tubular cells showed cell-protective role, however SCD1-treansgenic animal show little renopotective effect. We analyzed the relationship between the SNPs in SCD1 gene and the progression of diabetic nephropathy. However, we did not identify any relationship. Although, according to the result from clinical study, unsaturated FFAs may have a renoprotective role in diabetic nephropathy, further examination are needed to conclude the effectiveness of unsaturated FFAs on diabetic nephropathy
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| Free Research Field |
腎臓内科
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