Maternal exposure to high-fat and high-fructose diet evokes hypoadiponectinemia and kidney injury in rat offspring.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461239
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kurume University
• Principal Investigator: Fukami Kei 久留米大学, 医学部, 教授 (80309781)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腎障害 / アディポネクチン / 母体環境 / メタボリックシンドローム / 高血圧 / 酸化ストレス / アルブミン尿

Outline of Final Research Achievements

Maternal exposure to overnutrition during fetal development contributes torenal damage in offspring. Female Sprague-Dawley rats were fed either a standard (N) or a high-fat and high-fructose (HFF)-diet for 6 weeks before mating. After 4 weeks postpartum, all the offspring were fed N diet, and followed by 12 weeks. Serum adiponectin levels of 1-day- and 4-week-old HFF-offspring were significantly lower. Urinary albumin excretion levels werehigher than those of N-offspring at the same age, whose levels at 16-week old were inversely correlated with plasma adiponectin. HFF-offspring at 16-week old exhibited glomerulosclerosis, hyperglycemia, and high mean blood pressure associated with reduced podocin and increased transforming growth factor-beta1 expression in the kidneys. Exposure to maternal HFF-diet during fetal and early postnatal development induces hypoadiponectinemia in offspring, which might cause renal injury and metabolic derangements later in life.

Free Research Field

腎臓内科学