2015 Fiscal Year Final Research Report
Examination of the mechanism of the renal protection with the statin administration to hypertension-induced ApoE deficient mouse
| Project/Area Number |
25461261
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIZAKA Nobukazu 大阪医科大学, 医学部, 教授 (20270879)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 慢性腎臓病 / 高血圧 / 脂質異常症 / アンジオテンシン |
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| Outline of Final Research Achievements |
In ApoE deficient mouse with angiotensin II continuous infusion for 4 weeks as dyslipidemia combined hypertension model, glomerular swelling and sclerosis findings, and albuminuria were found. ARB olmesartan inhibited these renal injuries, but vasodilator hydralazine did not. Statin inhibited the renal injury as well as olmesartan. As the fatty deposition was restrictive, suggesting fatty accumulation is not a main mechanism of the renal injury in these mice. This renal injury is occurred when dyslipidemia and hypertension are combined, suggesting that this renal injury resembles early stage of CKD in human.
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| Free Research Field |
循環器内科
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