2015 Fiscal Year Final Research Report
Glucocerebrosidase associates with membrane trafficking system
| Project/Area Number |
25461290
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
Hatano Taku 順天堂大学, 医学部, 准教授 (60338390)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | Parkinson's disease / Glucocerebrosidase / Lipid enzymes |
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| Outline of Final Research Achievements |
It is well known that the impairment of glucocerebrosidase is associated with not only Gaucher disease, but also Parkinson's disease. This enzyme catalyzes the hydrolysis of glucosylceramide to form cderamide and glucose. Therefor, the impairment of GBA might induce the alteration of membrane composition. I revealed that GBA inhibition might induce the alteration of membrane trafficking and lysosome.
I investigated whether other lysosomal proteins might be associated with PD and found that one of lysosomal associated proteins also causes autosomal dominant familial PD. The impairment of the protein might induce the membrane trafficking perturbation and induce lysosomal dysfunction.
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| Free Research Field |
神経学
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