Regulation of the human resistin gene expression by SNPs, epigenetics, and environmental factors

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461359
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Ehime University
• Principal Investigator: OSAWA HARUHIKO 愛媛大学, 医学(系)研究科(研究院), 教授 (90294800)
• Co-Investigator(Kenkyū-buntansha): ONUMA HIROSHI 愛媛大学, 大学院医学系研究科, 准教授 (00294794) ; TAKATA YASUNORI 愛媛大学, 医学部附属病院, 講師 (20432792) ; KAWAMURA RYOICHI 愛媛大学, 医学部附属病院, 講師 (90533092)
• Co-Investigator(Renkei-kenkyūsha): TABARA YASUHARU 愛媛大学, 医学部附属病院, 講師 (00268749)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: レジスチン / インスリン抵抗性 / SNP / エピジェネティクス / 遺伝子発現 / 2型糖尿病 / 遺伝子 / 環境因子

Outline of Final Research Achievements

Resistin causes insulin resistance, a feature of type 2 diabetes. We analyzed how genetic, epigenetic, and environmental factors affected resistin gene expression. In 2078 subjects in the Japanese general population, plasma resistin was highest in the G/G genotype, followed by C/G and C/C. In contrast, the methylation at SNP-420 was highest in the C/C genotype, followed by C/G and G/G. When the methylation was assessed in the C/C or C/G genotype, the methylation was inversely associated with plasma resistin. Therefore, plasma resistin was associated with both the genotype and methylation at SNP-420.

Free Research Field

医歯薬学 代謝学　糖尿病　人類遺伝学　分子生物学