Development of novel therapies for diabetes by manipulating zinc transporters

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461364
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Juntendo University
• Principal Investigator: Fujitani Yoshio 順天堂大学, 医学(系)研究科(研究院), 准教授 (30433783)
• Co-Investigator(Kenkyū-buntansha): FUKUNAKA Ayako 順天堂大学, 大学院医学研究科, 研究員 (60586402)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 糖尿病 / 膵β細胞 / 亜鉛 / 亜鉛トランスポーター

Outline of Final Research Achievements

We showed that zinc ion secreted in concert with insulin from pancreatic beta cell suppressed hepatic insulin clearance by inhibiting clathrin-dependent insulin endocytosis.
In addition, we demonstrated that inactivation of Zip13 preferentially promotes beige adipocyte biogenesis, energy expenditure and ameliorates diet-induced obesity in mice. Our data reveal unexpected association between zinc homeostasis and beige adipocyte biogenesis, which may contribute significantly to novel therapies for diabetes.

Free Research Field

糖尿病学