2015 Fiscal Year Final Research Report
Downregulation of cPLA2 suppress atherosclerotic lesion formation in apolipoprotein-E deficient mice.
| Project/Area Number |
25461374
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SENOKUCHI Takafumi 熊本大学, 大学院生命科学研究部, 助教 (00530320)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MOTOSHIMA Hiroyuki 熊本大学, 医学部附属病院, 助教 (40398201)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 動脈硬化症 |
|---|
| Outline of Final Research Achievements |
We investigated the anti-atherogenic effects on cPLA2 and apoE double knockout mice (cPLA2/apoE KO mice). PPARgannma activity was increased in peritoneal macrophage of cPLA2/apoE KO mice. LPS-induced mRNA expression of TNF-alpha and MCP-1 was decreased, and mRNA expression ABCA1/G1 was increased in peritoneal macrophage of cPLA2/apoE KO mice. Moreover, atherosclerotic lesion formation on cPLA2/apoE KO mice was lower than that on control apoE KO mice. These results suggest that cPLA2 is involved in atherosclerotic lesion formation in apoE KO mice, and that may be therapeutic target for diabetic macrovascular complications.
|
| Free Research Field |
代謝学
|
