An approach to identify novel therapeutics against diabetic nephropathy based on aldosterone synthase gene regulation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461381
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Tohoku University
• Principal Investigator: Sugawara Akira 東北大学, 医学(系)研究科(研究院), 教授 (90270834)
• Co-Investigator(Renkei-kenkyūsha): ITO TAKAKO (SAITO TAKAKO) 東北大学, 病院, 助教 (10375173) ; KUDO MASATAKA 東北大学, 病院, 准教授 (20509583) ; HAKODA AKIKO (SAITO AKIKO) JR仙台病院, 小児科, 医長 (70509398) ; MATSUDA KEN 石巻赤十字病院, 内科, 副部長 (60645935)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アルドステロン / 糖尿病 / 高血圧 / CYP11B2 / 遺伝子改変マウス / DNAマイクロアレイ / 糖尿病性腎症 / 創薬

Outline of Final Research Achievements

We here have first demonstrated that high glucose (D-glucose) stimulates aldosterone synthase (CYP11B2) gene transcription and mRNA expression via the induction of transcription factor Nurr-1, and results in the increase of aldosterone secretion using human adrenocortical H295R cells. It is therefore suggested that high glucose levels in diabetic patients may promote hypertension, atherosclerosis, and diabetic nephropathy via the induction of aldosterone secretion.

Free Research Field

内分泌・代謝学