2015 Fiscal Year Final Research Report
Physiological roles of free fatty acids in the regulation of food intake
| Project/Area Number |
25461385
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | Wakayama Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | グレリン |
|---|
| Outline of Final Research Achievements |
Medium-chain triglycerides (MCTs) are triglycerides whose fatty acids have an aliphatic tail of 6-12 carbon atoms. Some studies have shown that MCTs can help in the process of excess calorie burning, because MCTs passively diffuse from the GI tract to the portal system and are used quickly. MCTs are also seen as promoting reduced food intake, but the mechanism by which MCTs reduces food intake is still unclear.
The aim of the study is to clarify whether medium fatty acids interfere with the biological activities of ghrelin. We used a mini-osmotic continuous infusion pump and kept plasma ghrelin levels 10-fold higher than control mouse. Cumulative food intake of standard-diet-fed mice were significantly increased, but those of MCT-diet-fed mice were not increased. These results suggest that May MCT diet may inhibit orexigenic effect of ghrelin.
|
| Free Research Field |
内分泌学
|
