Establishment of measurement and clinical indication of anti pendrin antibody

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461387
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Tottori University
• Principal Investigator: YOSHIDA Akio 鳥取大学, 医学(系)研究科(研究院), 特任教授 (90158428)
• Co-Investigator(Kenkyū-buntansha): HISATOME Ichiro 鳥取大学, 医学系研究科, 教授 (60211504)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Koichi 帝京大学, 医療技術部, 教授 (20206478)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 甲状腺 / ヨード / ペンドリン / イオン輸送体 / 陰イオン交換体 / 橋本病 / バセドウ病 / ELISA

Outline of Final Research Achievements

Autoimmune thyroid diseases are diagnosed by existence of autoーantibody against　thyroglobulin and/or thyro-peroxidase in the patients’ sera. Pendrin is　thyroid specific protein existｓ in the apical membrane of thyroid cells that transportｓ iodide. We have revealed that all of the patients with Hashimoto disease have anti-pendrin antibody in the sera using western blot analysis. We tried to establish ELISA for this antibody for the advance of diagnosis of autoimmune thyroid disease. We have obtained several results that will contribute the establishment of ELISA in the near future.

Free Research Field

代謝内分泌