Analysis of pathophysiology of myeloproliferarive neoplasms through the study of their abnormal lymphopoiesis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461413
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Mie University
• Principal Investigator: KATAYAMA NAOYUKI 三重大学, 医学(系)研究科(研究院), 教授 (20185812)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: がん幹細胞 / 骨髄増殖性腫瘍 / リンパ球造血

Outline of Final Research Achievements

We identified the seventh partner gene of PDGFRA, FOXP1, in a patient with myeloproliferative neoplasm with eosinophilia, harboring the chromosomal abnormality t(3;4)(p13;q12). Platelet counts of CALR-mutated patients tended to be higher
than those of JAK2-mutated patients. However, the occurrence of a thrombotic event was more frequently associated with CALR-mutated patients than with JAK2-mutated patients. The expression of IL-2R alpha on acute myeloid leukemia cells is a poor prognostic factor of acute myeloid leukemia patients ≦ 60 years old. Monocytes in the peripheral blood migrate into the pancreas at least partially through the MCP-1/CCR2 pathway and differentiate into pancreatic stellate cells. When transferred into hosts, tumor antigen-specific T cell receptor gene-engineered T cells retain the ex vivo antigen-specific tumor reactivity to persist for long period.

Free Research Field

医歯薬学