2015 Fiscal Year Final Research Report
Role of bone marrow niche in human early lymphopoiesis
| Project/Area Number |
25461447
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Mie University |
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Principal Investigator |
Ohishi Kohshi 三重大学, 医学部附属病院, 准教授 (00397506)
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| Co-Investigator(Kenkyū-buntansha) |
Tawara Isao 三重大学, 医学部附属病院, 助教 (80378380)
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| Co-Investigator(Renkei-kenkyūsha) |
Nosaka Tetsuya 三重大学, 医学系研究科, 教授 (30218309)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | ストローマ細胞 / SDF-1 / LFA-1 / リンパ球分化 |
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| Outline of Final Research Achievements |
By using coculture system with telomerized human bone marrow stromal cells, we found that stromal cell-derived factor 1 (SDF-1) is critical for stromal cell contact-induced early T- and B-lymphoid differentiation from human hematopoietic precursors but dispensable for early T-cell generation without contact with stromal cells and that LFA-1-mediated interaction with stromal cells is important for early T-lymphoid differentiation.
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| Free Research Field |
血液、輸血
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