Where and how are mature platelets produced?

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461458
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Iwate Medical University
• Principal Investigator: Ishida Yoji 岩手医科大学, 医学部, 教授 (70151389)
• Co-Investigator(Kenkyū-buntansha): KOWATA Syugo 岩手医科大学, 医学部内科学講座血液腫瘍内科分野, 教授 (30418884) ; ITO Shigeki 岩手医科大学, 医学部腫瘍内科学科, 教授 (60316362)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: megakaryocyte / thrombocytopoiesis / proplatelet / thick protrusion / immature platelet

Outline of Final Research Achievements

How and where mature platelets are produced were investigated. Two evidences were obtained. The first, megakaryocytes in the bone marrow extended the proplatelets into the sinusoid and the proplatelet snapped, resulting in the immature platelets were released into the sinusoid in a steady state. The second, in the emergency state, in which a lot of platelets were demanded in thrombocytopenia, another immature platelets called "thick protrusion" were released into the sinusoid. These two types of immature platelets were converted into the mature platelets in the circulation.

Free Research Field

巨核球・血小板造血