Investigation of a contribution of genes coding for paired receptors, LILR and LAIR families, to connective tissue diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461467
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: University of Tsukuba
• Principal Investigator: KAWASAKI Aya 筑波大学, 医学医療系, 助教 (30532816)
• Co-Investigator(Renkei-kenkyūsha): TSUCHIYA Naoyuki 筑波大学, 医学医療系, 教授 (60231437)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 全身性エリテマトーデス / 全身性強皮症 / 疾患感受性遺伝子 / LILR / HLA-G / 多型

Outline of Final Research Achievements

To examine whether genes coding for paired receptors, leukocyte immunoglobulin (Ig)-like receptors (LILR), and one of their ligands, HLA-G, contribute to susceptibility to connective tissue diseases such as systemic lupus erythematosus (SLE), association study of LILR and HLA-G genes was conducted in a Japanese population. LILRA3 deletion allele was significantly increased in patients with systemic sclerosis with anti‐topoisomerase I antibodies. With respect to HLA-G, 14bp insertion allele in 3’ untranslated region was associated with SLE with the age of onset <20 years independently of the SLE　susceptible and protective HLA-DRB1 alleles.

Free Research Field

ゲノム医科学、膠原病学