2015 Fiscal Year Final Research Report
Functional analysis of the protein phosphatase expressed in dendritic cells
| Project/Area Number |
25461468
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Gunma University |
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Principal Investigator |
KANEKO YORIAKI 群馬大学, 医学部附属病院, 講師 (00334095)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 自己免疫疾患 / ホスファターゼ |
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| Outline of Final Research Achievements |
We generated a conditional knockout mouse (Shp-1 cKO) in which Shp-1, an intracytoplasmic tyrosine phosphatase, is specifically depleted in dendritic cells (DCs). Shp-1 cKO developed autoimmune nephritis with aging, which was characterized by massive infiltration of macrophages and T cells. The cells prepared from the kidneys of Shp-1 cKO were able to produce large amounts of inflammatory cytokines, therefore we conclude Shp-1 in DCs acts as a negative regulator for the development of autoimmune nephritis.
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| Free Research Field |
膠原病
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