Human papillomavirus genotypes and HPV16 E6/E7 variants among patients with genital cancers in Asia

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461509
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Kanazawa University
• Principal Investigator: ICHIMURA HIROSHI 金沢大学, 医学系, 教授 (10264756)
• Co-Investigator(Kenkyū-buntansha): SASAGAWA Toshiyuki 金沢医科大学, 医学系, 教授 (30272975)
• Co-Investigator(Renkei-kenkyūsha): ISHIZAKI Azumi 金沢大学, 医学系, 助教 (30456420) ; BI Xiuqiong 金沢大学, 医学系, 助教 (50565413)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ヒトパピローマウイルス / がん化 / HPV遺伝子型 / HPV E6・E7亜型 / ベトナム / 子宮頚癌 / 生殖器癌

Outline of Final Research Achievements

This study aimed to investigate human papilloma virus (HPV) genotype distribution and the HPV16 E6/E7 variations in Vietnamese patients with genital cancers, such as cervical, vulvar/vaginal, and penile cancers. The most prevalent HPV genotype in the women with normal cervical cytology (HPV52) was different from those in patients with genital cancers (HPV16/18). More than 85% of genital cancers could be prevented with the current vaccine targeting HPV 16/18 in Vietnam. HPV16 E6/E7 European Asian lineage may be less oncogenic. The G to A and C to T mutations at specific nucleotide positions of HPV16 E6/E7 genes may be involved in the development of cancers.

Free Research Field

ウイルス学、感染症制御学、国際保健学