2015 Fiscal Year Final Research Report
Involvement of double-stranded RNA in the pathogenesis of prion disease
| Project/Area Number |
25461514
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Fukuoka University (2014-2015)
Nagasaki University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | プリオン / dsRNA / 感染 |
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| Outline of Final Research Achievements |
Although the pathogenesis of prion disease has not been clarified fully, it is widely accepted that prion disease occurs through autocatalytic conformational conversion of the ubiquitous normal form of prion protein (PrPC) to PrPSc in a protein only manner. Meanwhile, activation of the innate immune system has been suggested to partially block the progression of prion disease. Furthermore, different prion strains can interfere with each other, and this is known as prion strain interference. The results suggest that cofactors, such as virus derived nucleic acids, involve in prion propagation. In this study, we demonstrated that double-stranded RNA innate immune responses play a key role in the pathogenesis of prion disease.
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| Free Research Field |
神経分子病態学
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