Study of the effect of bisphosphonate on osteocyte function and bone formation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461548
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Osaka University
• Principal Investigator: Kitaoka Taichi 大阪大学, 医学(系)研究科(研究院), 助教 (20599229)
• Co-Investigator(Kenkyū-buntansha): NAMBA Noriyuki 大阪大学, 大学院医学系研究科, 招聘教員 (10379076)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: スクレロスチン / 骨形成不全症 / ビスホスホネート / 骨代謝マーカー

Outline of Final Research Achievements

We examined the levels of sclerostin, an inhibitor of bone formation, during bisphosphonate treatment in patients with osteogenesis imperfecta, and evaluated the influence of bisphosphonate on bone formation. Serum sclerostin concentration did not change significantly during the bisphosphonate treatment. On the other hand, bone-specific alkaline phosphatase (BAP), a bone formation marker, was associated significantly with the change of sclerostin levels. Since the levels of BAP gradually increased during childhood, it was suggested that the change of sclerostin levels may, in part, contribute to the effect of bone formation with bisphosphonate treatment and the growth.

Free Research Field

医歯薬学, 内科系臨床医学, 小児科学, 小児内分泌学