A new strategy for the treatment of rett syndrome with ghrelin and bone marrow transplantation

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461570
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kurume University
• Principal Investigator: Nishi Yoshihiro 久留米大学, 付置研究所, 研究員 (20352122)
• Co-Investigator(Renkei-kenkyūsha): KOJIMA Masayasu 久留米大学, 分子生命科学研究所, 教授 (20202062) ; SATOU Motoyasu 獨協医科大学, 生化学, 助教 (20418891)
• Research Collaborator: NASU Saori 久留米大学, 医学部・放射線同元素施設, 研究員 (90754359)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: グレリン / レット症候群 / 骨髄移植 / 放射線障害

Outline of Final Research Achievements

Rett syndrome(RTT) is a congenital neurodeveropmental disease with glial disfunction. Derecki NC reported that, in RTT-model mice (RTT mice), an exchange of abnorlmal glial cells to normal ones by bone marrow transplantation (BMT) partially ameliorated neuronal disoders together with an elongation of thier life-span. Ghrelin, a brain-and-gut hormone, has been reported to calm down the hyper-excited glial cells through the functional ghrelin-receptor on them. In this study, we injected ghrelin once a day for 14 days to BMT-treated or non-BMT-tereated RTT mice and checked thier neuronal phenotype according to the method of Derecki NC. We also checked their life-span. In BMT-RTT mice with or without ghrelin-injection, we could find out no significant evidence for the elongation of life-span nor amelioration of neuronal condition in comparison to non-BMT RTT mice. Although, in non-BMT RTT mice with ghrelin-treatment, significant improvement of their neuronal condition was revealed.

Free Research Field

内分泌・代謝