2015 Fiscal Year Final Research Report
Study of new IL-18 inhibitors and molecular targeting molecules for beta-trefoil cytokines
| Project/Area Number |
25461588
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Gifu University |
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Principal Investigator |
Kato Zenichiro 岐阜大学, 医学(系)研究科(研究院), 教授 (90303502)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | IL-18 |
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| Outline of Final Research Achievements |
The binding mode of IL-18 was determined at atomic resolution to investigate the complex structure of Il-18 ligand, Il-18 receptor alpha, and IL-18 receptor beta. The candidate drugs were obtained through the structural information. The candidates have different mode of inhibition from those we obtained before this study. The new molecular mechanism of the future drugs will open up a new avenue for drug development, especially for the beta-trefoil cytokines including IL-1,IL-18 and IL33.
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| Free Research Field |
小児科学
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