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2015 Fiscal Year Final Research Report

Analysis of the factor of low immune responses to pneumococcal conjugate vaccine and Hemophilus influenzae type b conjugate vaccine in immunocompromised children

Research Project

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Project/Area Number 25461598
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

HOSHINA Takayuki  産業医科大学, 医学部, 助教 (30398078)

Co-Investigator(Kenkyū-buntansha) NISHIO Hisanori  九州大学, 大学病院, 助教 (00507783)
Co-Investigator(Renkei-kenkyūsha) OHGA Shiouichi  山口大学, 医学部, 教授 (60233053)
OISHI Kazunori  国立感染症研究所, 感染症疫学センター, センター長 (80160414)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords免疫不全 / 結合型肺炎球菌ワクチン / 免疫応答低下 / メモリーB細胞 / ヘルパーT細胞
Outline of Final Research Achievements

The aim of this study is to investigate the factor of low immune response to pneumococcal conjugate vaccine and Hemophilus influenzae type b conjugate vaccine in immunocompromised children.
We measured anti-pneumococcal IgG antibodies and opsonization index and anti-Hemophilus influenzae type b antibody and serum bactericidal antibody after the vaccinations in immunocompromised children [children who underwent hematopoietic stem cell transplantation (HSCT) and the patients with immunosuppressive treatments] and immunocompetent children. Anti-pneumococcal IgG antibodies and opsonization index in the patient after HSCT were significantly lower than those in immunoponpetent children. In addition, memory B cell and CD4+ T cell counts in the patients after HSCT were lower than those in immunocompetent children, suggesting that these cells might have an important role in the immune response to conjugate vaccine.

Free Research Field

小児感染症学

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Published: 2017-05-10  

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