Exploring causal genes in susceptibility loci associated with atopic dermatitis and common genetic factors among allergic diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461612
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Hirota Tomomitsu 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 (50435674)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アレルギー / アトピー性皮膚炎 / GWAS / SNP / 関連遺伝子

Outline of Final Research Achievements

For a better understanding of the pathological mechanisms underlying AD, we sought to identify the potential causal gene in an AD-associated locus (3p21.33) identified by AD GWAS. We investigated eQTL databases, and conducted analyses for histone modification (methylation and acetylation) and three-dimensional chromatin structure in this region. We confirmed that DNA sequence in an intron of the GLB1 gene at the locus is presumed to regulate CCR4 gene expression. These findings suggest that CCR4 is a plausible candidate gene in the region.

Free Research Field

遺伝学