Elucidation of subcellular signals in mesangial proliferative glomerular nephritis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461617
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: The University of Tokyo
• Principal Investigator: TSURUMI HARUKO 東京大学, 医学部附属病院, 登録研究員 (20632269)
• Co-Investigator(Kenkyū-buntansha): HARITA YUTAKA 東京大学, 医学部附属病院, 講師 (10451866) ; HATTORI MOTOSHI 東京女子医科大学, 医学部, 教授 (50192274) ; KURIHARA HIDETAKE 順天堂大学, 医学部, 准教授 (80311976)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 小児腎・泌尿器学 / 病理学 / 細胞・組織 / シグナル伝達

Outline of Final Research Achievements

We examined precise localization of F-actin binding protein EPLIN and intercellular junction protein Afadin in mesangial cells in vivo and in vitro and found alteration of expression and localization of these cytoskeletal regulators underlies phenotypical change of mesangial cells induced by mitogens (Tsurumi H. et al. Kidney Int. 2014, Tsurumi H. et al. Lab Invest. 2016). Comprehensive investigation of spatiotemporal dynamics of mesangial intercellular molecules is warranted to elucidate precise mechanisms of mesangial proliferative glomerulonephritis.

Free Research Field

医歯薬学