2016 Fiscal Year Final Research Report
The clarification of the pathophysiology of small bacterial overgrowth in neurologically impaired patient by using non-invasive technique
| Project/Area Number |
25461636
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 小腸内細菌増殖 / 重症心身障害児 / 水素呼気テスト |
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| Outline of Final Research Achievements |
Hydrogen breath test was conducted for 33 case of neurologically impaired patients (mean: 19.0 years, ranged 1 to 58 years). Three and 6 cases of all patients were determined as positive and pseudo-positive small bowel bacterial overgrowth (SBO), respectively. All cases administered anticonvulsant and one case administered gastric secretion inhibitor. All enrolled cases were not diagnosed as gastroesophageal reflux disease (GERD) by esophageal impedance monitoring, whereas demonstrated delayed gastric emptying (132.9-241.3 min).
The present study suggested that approximately 10% of neurologically impaired patients potentially suffers SBO although there was no significant relationship between SBO and clinical parameters, drugs, GERD and delayed gastric emptying, statistically.
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| Free Research Field |
小児消化管生理学
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