A Study on Cerebral Protection Mechanism against Neonatal Asphyxia: Treatment strategy Based on Brain Glycogen Metabolism

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461652
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Tokoha University (2014-2016); Jichi Medical University (2013)
• Principal Investigator: SUGIE Hideo 常葉大学, 保健医療学部, 教授 (60119980)
• Co-Investigator(Renkei-kenkyūsha): FUKUDA Tokiko 浜松医科大学, 小児科, 准教授 (10458268) ; KONO Yumi 自治医科大学, 小児科, 教授 (50243390) ; HIRASAWA Kyoko 東京女子医科大学, 小児科, 准教授 (50316709)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 新生児仮死 / 神経後遺症 / 脳性麻痺 / グリコーゲン / 嫌気性解糖 / アストロサイト / 遺伝子多型

Outline of Final Research Achievements

In this study, brain glycogen phosphorylase gene（PYGB) polymorphism, which is an enzyme involved in the first step of anaerobic glycolysis, was investigated as a factor modifying the cerebral metabolism during the ecent on neonatal asphyxia. Subjects experienced similar degree of neonatal asphyxia including with typical development and neurological sequelae were used. As a result, in the poor prognostic group, there was a significant difference in gene polymorphisms in exons 12 and 14 of the PYGB gene. By using this gene polymorphism it is necessary to verify whether it can be established as a biomarker that can estimate the neurological prognosis of a child exposed to asphyxia in newborn and whether it can be an important evidence for early treatment and therapy .

Free Research Field

小児科学、小児神経学