2015 Fiscal Year Final Research Report
Effects and mechanism analysis of zinc ion on neural tube defects
| Project/Area Number |
25461653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOMATA Reiko 埼玉医科大学, 医学部, 助手 (50468378)
KAMEZAWA Hajime 埼玉医科大学, 医学部, 助手 (50646677)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 神経管閉鎖障害 / 二分脊椎 / 亜鉛イオン / 両生類 / 神経胚形成 |
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| Outline of Final Research Achievements |
Neural tube defects (NTDs) are birth defects of the brain and spinal cord. NTDs are caused relatively at a high frequency in the newborn, and the symptoms are severe. The exact causes and mechanisms of NTDs are unclear. Many different factors, such as, genetics, environmental pollution, and nutrition (excess or deficiency of vitamin B and zinc ion) are likely to play a role. We analyzed the effects of excess zinc ions on neural tube formation of amphibian (newt) embryos in order to clarify the mechanism by which NTDs are caused. In this study, specific effects of zinc ions on the developing brain and spinal cord in amphibian embryos were demonstrated, and some mechanism of NTDs induced by zinc ions was revealed.
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| Free Research Field |
発生生物学・細胞生物学
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