Selection of biomarkers for the evaluation of therapeutic efficacy of severe cutaneous adverse drug reactions

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461676
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kyorin University
• Principal Investigator: KANO Yoko 杏林大学, 医学部, 客員教授 (20142416)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: Stevens-Johnson症候群 / 中毒性表皮壊死症 / 薬剤性過敏症症候群

Outline of Final Research Achievements

There have been no biomarkers found which can predicting progression to severe cutaneous adverse drug reactions (SCARs). Therefore, there is an urgent need for reliable and standard laboratory tests for identifying patients at higher risk of developing SCARs. A variety of cytokines/chemokines in the serum in patients who presented with clinical symptoms suggestive of SCARs were retrospectively measured using multiplex biometric immunoassay. Our results showed that several biomarkers altered in combinations depending on the clinical type of SCARs such as Stevens-Johnson syndrome and toxic epidermal necrolysis, although each biomarker was not sufficiently sensitive or specific on its own.
The evaluation of these markers in combinations could increase the diagnostic and prognostic utility for the prediction of SCARs. Furthermore, the measurements of these selected markers at the initial stage could contribute to the appropriate selection of treatment modalities for SCARs.

Free Research Field

医歯薬学