2015 Fiscal Year Final Research Report
Keratinocyte differentiation mediated by IL-22
| Project/Area Number |
25461697
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
Tohyama Mikiko 愛媛大学, 医学(系)研究科(研究院), 准教授 (60263935)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 表皮角化細胞分化 / IL-22 / フィラグリン / k10 / IL-22R1 / アトピー性皮膚炎 / 乾癬 |
|---|
| Outline of Final Research Achievements |
IL-22 plays important roles in the pathogenesis of atopic dermatitis and psoriasis vulgaris. IL-22 affects the differentiation of epidermal keratinocytes. The receptor for IL-22 is a complex of the IL-22R1 and IL-10R2. Expression levels of IL-22R1 increase in the epidermis of psoriasis, which induces strong STAT3 phosphorylation, but not in that of atopic dermatitis. We examined the influence of IL-22R1 expression levels on the regulation of differentiation marker expressions in keratinocytes treated with IL-22.
|
| Free Research Field |
皮膚科学
|
