Pharmacogenetics of abnormal glucose metabolism and weight gain induced by atypical antipsychotics

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461725
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Niigata University
• Principal Investigator: Fukui Naoki 新潟大学, 医歯学系, 助教 (90535163)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 抗精神病薬 / 糖代謝異常 / 脂質代謝異常 / 体重増加 / 薬理遺伝学

Outline of Final Research Achievements

Meta-analysis of genome-wide association studies (GWAS) have detected several genetic markers related with glucose metabolism and obesity. We have examined relationships between these genetic markers and abnormal glucose metabolism and weight gain induced by atypical antipsychotics. Consequently, we found that, ⅰ) there may be different effects of the various antipsychotics on incretin secretion, ⅱ) the relationship between Trib1 gene and abnormal lipid metabolism, ⅲ) the relationship between GIPR gene and abnormal lipid metabolism.

Free Research Field

精神医学