Role of calcium ion-dependent signaling pathway in the perirhinal cortical neurons related to visual memory

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461735
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Health Sciences University of Hokkaido (2015-2016); University of Miyazaki (2013-2014)
• Principal Investigator: ABE Hiroshi 北海道医療大学, 心理科学部, 准教授 (20344848)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 視覚性記憶 / 嗅周皮質 / シグナル伝達

Outline of Final Research Achievements

Memory impairment in Alzheimer's disease is associated with lesion of the perirhinal cortex. The calcium ion-dependent information transmission in this cortex is indispensable for the visual memory. In this study, we aimed to examine the behavioral and morphological relationships between annexin AII and visual memory associated with one of the calcium - dependent signal transduction pathways. The operant conditioning was used to make rats learn the visual memory task. This was impaired by damage of the perirhinal cortex. However, annexin AII in this cortex was not so involved in this memory, suggesting that other signal transduction pathways might play an important role.

Free Research Field

心理学