The neural basis of depression based on the auditory change detection

2017 Fiscal Year Final Research Report

• Project/Area Number: 25461763
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Mie University
• Principal Investigator: MOTOMURA Eishi 三重大学, 医学部附属病院, 講師 (10324534)
• Co-Investigator(Kenkyū-buntansha): 前田 正幸 三重大学, 医学系研究科, 教授 (70219278) ; 乾 幸二 生理学研究所, システム脳科学研究領域, 准教授(兼任) (70262996)
• Co-Investigator(Renkei-kenkyūsha): TANII Hisashi 三重大学, 医学系研究科, 准教授 (40346200) ; SHIROYAMA Takashi 三重大学, 医学部附属病院, 講師 (00252354)
• Research Collaborator: OHOYAMA Keiko
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: うつ病 / 誘発電位 / 誘発磁場 / 変化関連脳活動

Outline of Final Research Achievements

The change-related cerebral response, an auditory evoked potential measured by electroencephalography (EEG) or magnetoencephalography (MEG), is speculated to reflect the neural processing of sensory changes, which is essential for survival. Here we investigated the neural basis of depression by using the change-related cerebral response. We obtained the following findings. (1) The change-related response might be affected by personality traits, particularly anxiety- or depression-related traits. (2) The healthy subjects with Met carrier showed significantly higher amplitudes of the off-response compared to subjects with Val/Val in the BDNF polymorphisms. (3) The amplitude of the change-related response was significantly higher in the depressive patients compared to the healthy controls. These results suggest that high sensitivity of the change detection system might be a feature of predisposition to depression.

Free Research Field

精神生理学