2015 Fiscal Year Final Research Report
The research of social experience-dependent development of prefrontal excitatory neural circuit for psychiatric treatment
Project/Area Number |
25461778
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
|
Research Institution | Nara Medical University |
Principal Investigator |
Yoshino Hiroki 奈良県立医科大学, 医学部, 講師 (10347560)
|
Co-Investigator(Renkei-kenkyūsha) |
MAKINODAN Manabu 奈良県立医科大学, 医学部, 助教 (00510182)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 前頭葉 / 社会経験 / 興奮性 / 神経細胞 / 発達 |
Outline of Final Research Achievements |
To elucidate how social experience during early childhood influence the development of prefrontal cortex, we compared the electrical activity of layer 5 pyramidal cell of medial prefrontal cortex in adulthood between isolate-housing mouse (be housed in isolation from postnatal 21 day to 35 day) and group-housing mouse. We found that the pyramidal cells of isolate-housing mouse has lower excitability than that of group-housing mouse, and the frequency of excitatory inputs into the pyramidal cell is lower in isolate-housing mouse than in group-housing mouse. Furthermore once we classified the pyramidal cells into two groups by the electrical character, we found that only one group of the pyramidal cells was influenced by social isolation.
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Free Research Field |
精神医学
|