Reoxygenation by radiation for dose escalated radiation therapy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461797
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: OKAMOTO SHOZO 北海道大学, 大学病院, 助教 (20431364)
• Co-Investigator(Kenkyū-buntansha): YASUDA KOUITI 北海道大学, 大学院医学研究科, 特任助教 (00431362) ; SHIGA TOHRU 北海道大学, 大学院医学研究科, 准教授 (80374495)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: FMISO

Outline of Final Research Achievements

We performed FMISO-PET (pre-therapeutic, inter-therapeutic, and post-therapeutic) studies for 20 patients in accordance with our protocol. Tumor hypoxia was observed in 19 patient on pre-therapeutic FMISO-PET.
FMISO uptake at the inter-therapeutic PET reduced than that at the pre-therapeutic PET in all patients. Tumor hypoxia disappeared at the inter-therapeutic PET in ten patients in these 19 patients. Seven patients showed disappearance of tumor hypoxia at the post-therapeutic PET. However, tumore hypoxia remained in 2 patients.
These results indicates that reoxygenation occurred in the early phase of radiation course by intensity-modulated radiation therapy.

Free Research Field

核医学