Consideration as a Drug delivery system of newly developed superparamagnetic iron oxide.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461813
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Watanabe Shobu 滋賀医科大学, 医学部, 特任助教 (60570364)
• Co-Investigator(Kenkyū-buntansha): NITTA Norihisa 滋賀医科大学, 医学部, 准教授 (40324587)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 酸化鉄ナノ粒子 / ドラッグデリバリーシステム

Outline of Final Research Achievements

We evaluated the anti-tumor effect using the newly developed negatively charged superparamagnetic ion-oxide (SPIO) nanoparticles created by changing the reaction time with cisplatin and the diameter of the particles.
In this study, negatively charged SPIO nanoparticle was combined with cisplatin well than conventional SPIO. Although the Iron concentration in the tumor tissue was higher in a small size of SPIO, Platinum concentration was lower in the tumor tissue. The reaction time did not have a clear influence on the antitumor effect. Further studies are necessary, such as conditions of the release of the drug, negatively charged SPIO nanoparticle can be expected to become an effective contrast agent also as drug delivery system.

Free Research Field

医師薬学