Heterogeneity of sympathetic nerve pre-synaptic function in the left ventricular wall in patients with dilated cardiomyopathy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461840
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagoya City University
• Principal Investigator: Ohte Nobuyuki 名古屋市立大学, 医学(系)研究科(研究院), 教授 (10185332)
• Co-Investigator(Kenkyū-buntansha): Nakagawa Motoo 名古屋市立大学, 医学研究科, 講師 (60590982)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 心不全 / PET / 心筋血流 / 心臓交感神経 / ammonia / hydroxyephedrine

Outline of Final Research Achievements

N-13 ammonia positron emission tomography (PET) for quantitative myocardial blood flow (MBF) measurement and C-11 hydroxyephedrine (HED) PET for quantitative sympathetic nerve pre-synaptic function evaluation were performed in 15 patients with dilated cardiomyopathy (DCM) and in 15 healthy volunteers. Both MBF and HED-RI of the whole left ventricle were significantly reduced in patients with DCM than in healthy volunteers. Heterogeneities of MBF and HED-RI among the segmental left ventricular walls were significantly greater in the DCM patients than in the healthy volunteers. Such heterogeneities of MBF and HED-RI as well as the reduction of both is related to the pathophysiology of heart failure in patients with DCM.

Free Research Field

循環器内科学