Multifaced imaging analysis in patients with intractable epilepsy: a study for surgical treatment approach

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461865
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Sato Noriko 国立研究開発法人国立精神・神経医療研究センター, 病院 放射線診療部, 部長 (10322017)
• Co-Investigator(Renkei-kenkyūsha): SASAKI Masayuki 国立精神・神経医療研究センター病院, 小児神経診療部, 部長 (60235273)
• Research Collaborator: SONE Daichi ; KIMURA Yukio
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: てんかん / 画像解析 / MRI

Outline of Final Research Achievements

Multifaced imaging analyze was done in patients with intractable epilepsy. Ipsilateral temporal cortex was thickened in 60% temporal epilepsy (TLE) patients with amygdala enlargement, whose pathology was proved to be cortical dysplasia. The white matter volume and FA value were significantly decreased in patients with TLE with hippocampal sclerosis comparing to TLE with amygdala enlargement. These results showed that the etiology was different between them. Subfield volumetric analysis using high resolution T2WI demonstrated decreased volume of C1, C4, and dentate nucleus in patients with hippocampal sclerosis. Graph analysis detected cerebral fragility at temporooccipital and lateral frontal lobes in patients with idiopathic generalized epilepsy. These methods seem to be useful for speculating their pathology and planning their treatments.

Free Research Field

医歯薬学