Revealing the pathological condition of a rabbit model for spontaneous myocardial infarction (WHHLMI rabbit) using MRI

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461867
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Enmi Jun-ichiro 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 (80393205)
• Research Collaborator: SHIOMI Masashi ; SATO Hiroshi ; NAKAO Kazuhiro
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 動脈硬化 / プラーク / WHHLMI / 画像診断 / MRI

Outline of Final Research Achievements

Heart and cerebrovascular diseases, which are attributed mainly to arteriosclerosis, are major causes of death in Japan. Improvement in the diagnosis and treatment of arteriosclerosis is a pressing issue. The WHHLMI rabbit is an animal model for spontaneous myocardial infarction due to arteriosclerosis and expected to be a useful model animal for preclinical research of arteriosclerosis. However, the pathological condition of WHHLMI rabbits is still not fully understood. We developed an MRI system for noninvasive in vivo evaluation of cardiac function in rabbits in order to reveal the pathological condition of myocardial infarction in WHHLMI rabbits. The results suggested the cardiac depression in WHHLMI rabbits. WHHLMI rabbits will be useful for preclinical research of arteriosclerosis.

Free Research Field

画像診断学