To investigate the clinical application of alpha-defensin in stool in the objective evaluation of radiation enteritis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461899
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido Cancer Center(Department of Clinical Research) (2014-2015); Hokkaido University (2013)
• Principal Investigator: Onodera Shunsuke 独立行政法人国立病院機構北海道がんセンター(臨床研究部), その他部局等, その他 (30374458)
• Co-Investigator(Kenkyū-buntansha): Nakamura Kiminori 北海道大学, 大学院先端生命科学研究院自然免疫研究室, 准教授 (80381276)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 放射線腸炎 / α-defensin / 腸内細菌叢

Outline of Final Research Achievements

The purpose of this study was to investigate the clinical application of α-defensin in stool in the objective evaluation of radiation enteritis.As the first step, we experimented on mice and found that the amount of α-defensin significantly decreased in stool of mice irradiated to the abdomen.In addition, a significant negative correlation was observed between the amount of α-defensin and Firmicutes at three days after irradiation.These results suggested that decrease of α-defensin correlated with an altered intestinal flora of the mice irradiated to the abdomen.We could not investigate the clinical application due to insufficient number of patients in this period.

Free Research Field

放射線腫瘍学