Research of IGRT using calcium phosphate paste

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461922
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Yokohama City University
• Principal Investigator: Ogino Ichiro 横浜市立大学, 附属市民総合医療センター, 准教授 (20275035)
• Co-Investigator(Renkei-kenkyūsha): OOMURA Susumu 横浜市立大学, 附属市民総合医療センター, 准教授 (50145687)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: fiducial marker / radiation therapy / cervical cancer

Outline of Final Research Achievements

A volume of 0.1-0.2 mL of the calcium phosphate cement (CPC) paste was injected using a 19-gauge long needle. Six cervical cancer patients received 3-5 injections of CPC paste placed at a depth of 10 mm into tumors of the cervix before treatment planning CT (TPCT). Patients were first treated with external beam radiotherapy (EBRT) to the whole pelvis in 27-28 fractions. Two to three sessions of fractionated high-dose rate brachytherapy (BT) were performed. There was no interruption of the implantation. Of a total of 22 visible CPC markers at TPCT, 17 CPC markers were visible on the first CBCT. All markers were lost in one patient before or during EBRT. Excluding one patient, all markers were visible on CBCT during EBRT. Of 16 visible CPC markers on CBCT, 13 CPC markers were visible on the MRI obtained before BT. This is the first report of a CPC marker injected into tumors of the cervix. It can be visualized on CBCT and MRI with reductions in marker loss and artifacts.

Free Research Field

Radiation Oncology