2016 Fiscal Year Final Research Report
Targeted delivery of anti-cancer-drug using nanocapsules, directed by radiotherapy.
| Project/Area Number |
25461924
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | ドラッグデリバリー / 放射線治療 / 癌化学療法 / PIXE / micro PIXE camera |
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| Outline of Final Research Achievements |
We aimed to image malignant tumors by 2 radiotherapy sessions In the first session, we injected CT-detectable microcapsules with P-selectin to observe malignant tumors by VEGFR-1/2 and αvβ3antibody-antigen complex accumulation. In the second session, we performed chemo-radiotherapy using microcapsules which have a high affinity for P-selectin and PSGL-1.
In the first session, anti-VEGFR-1/2 and anti-αvβ3microcapsules accumulated in the malignant tumor, which could be detected by CT. These microcapsules released P-selectin and PSGL-1 in response to the first irradiation. Subsequently, microcapsules for tumor treatment were injected. Those microcapsules accumulated around the tumor through P-selectin-antigen-antibody reaction. In the second session, microcapsules released carboplatin. The released carboplatin attacked synertistically with radiation, which resulted in increased antitumor effect. And localization of carboplatin by capsules reduced adverse effect.
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| Free Research Field |
放射線腫瘍学
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