Devlopment of novel immunosupression to regulate complement in intestinal transplant

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461945
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Osaka University
• Principal Investigator: UENO Takehisa 大阪大学, 医学(系)研究科(研究院), 助教 (10456957)
• Co-Investigator(Kenkyū-buntansha): MASAHATA Kazunori 大阪大学, 医学部付属病院, 医員 (40588381) ; YAMAMITI Taku 大阪大学, 医学部付属病院, 医員 (30715165) ; UMEDA Satoshi 大阪大学, 医学部付属病院, 医員 (60715176)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 小腸移植 / 拒絶 / 補体 / 補体制御 / ラット / 虚血再灌流

Outline of Final Research Achievements

Intestinal transplant is poor result comparing with other organ transplant. Current immunosuppression cannot regulate rejection. Especially antibody has a role for rejection so that novel immunosuppression to control them. Recently it was reported that expression of complement and complement regulatory factor have a major role for T cell related rejection. We investigated expression of complement and complement regulatory factors, then the relationship was revealed using ischemia and reperfusion rat model mimicking intestinal transplant.

Free Research Field

小児外科