2015 Fiscal Year Final Research Report
Novel therapeutic development with the target of cancer cell eradication against cancer stem cells
| Project/Area Number |
25461953
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Iguchi Tomohiro 九州大学, 大学病院, 助教 (30598959)
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| Co-Investigator(Renkei-kenkyūsha) |
Mimori Koshi 九州大学, 大学病院, 教授 (50322748)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 癌幹細胞 / 癌免疫治療 / 樹状細胞療法 / 癌抗原 / PD-1 / HLA class I |
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| Outline of Final Research Achievements |
We identified a Plastin3 (PLS3) that was only detectable in the metastasis by comprehensive genetic analysis using a sample of colon cancer cases. It was confirmed that cancer cells introduced PLS3 were promoting the epithelial-mesenchymal transition (EMT) and the cancer stem cells.
Cancer cell-killing effect of cytotoxic T cell was reduced. Because the binding of PD-L1 on cancer cell to PD-1 on lymphocyte transmits an inhibitory signal which reduces the proliferation of cytotoxic T cells. High expression of both HLA class I and PD-L1 had a high recurrence rate and poor prognosis.
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| Free Research Field |
消化器外科
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