The Elucidation of an Immune Escape Mechanism and its control in Gastrointestinal Cancers

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461955
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kagoshima University
• Principal Investigator: Arigami Takaaki 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (40527058)
• Co-Investigator(Kenkyū-buntansha): UENOSONO YOSHIKAZU 鹿児島大学, 医歯学総合研究科, 特任准教授 (60398279) ; NATSUGOE SHOJI 鹿児島大学, 医歯学域医学系, 教授 (70237577) ; OKUBO Keishi 鹿児島大学, 医学部・歯学部附属病院, 医員 (40772223)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 癌免疫機構 / 好中球リンパ球比 / Fibrinogen / 全身性炎症反応 / 胃癌

Outline of Final Research Achievements

We focused on CD3+ tumor-infiltrating lymphocytes (CD3+ TILs), neutrophil-lymphocyte ratio (NLR), and fibrinogen in this study. The numbers of CD3+ TILs in patients with gastric cancer were lower than those in gastric adenoma. Moreover, CD3+ TILs was inversely correlated with tumor progression and prognosis in patients with gastric cancer. On the other hand, the values of NLR and fibrinogen were significantly correlated with advanced disease. Patients with high NLR and fibrinogen status had poorer prognosis than those with low status. Consequently, our findings suggest that the systemic inflammatory response induced by tumor cells suppress host immune response and its escape mechanism from host immune surveillance produces tumor invasion and metastases.

Free Research Field

医歯薬学