2016 Fiscal Year Final Research Report
Involvement of EMT in anaplastic thyroid carcinoma
| Project/Area Number |
25461992
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Osaka City University |
|---|
Principal Investigator |
Onoda Naoyoshi 大阪市立大学, 大学院医学研究科, 准教授 (30295703)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 甲状腺癌 / 未分化癌 / 培養細胞株 / 上皮間葉転換 |
|---|
| Outline of Final Research Achievements |
Both OCUT-1C and OCUT-1F was the human anaplastic thyroid cancer cell lines derived from a single original tumor, and demonstrated same DNA profile. OCUT-1C showed epithelial phenotype with E-cadherin expression, whereas OCUT-1F displayed mesenchymal phenotype by losing E-cadherin expression for unknown reason. E-cadherin expression was inhibited in OCUT-1C by the exposure to TGF-beta. Still, no morphological change was recognized at the same time.
Markers indicating the mesenchymal phenotype were commonly found in the clinical samples of anaplastic thyroid cancer. Nestin, one of these markers, expression was suggested to be a poor prognostic indicator, independent of the clinical features of the patients
|
| Free Research Field |
内分泌外科学
|
