2015 Fiscal Year Final Research Report
The function of intraperitoneal macrophage and its tumorigenesis in gastic cancer with peritoneal metastasis
| Project/Area Number |
25462015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HARADA SHINICHI 金沢大学, 医学系, 助教 (90272955)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 胃癌 / 腹膜播種 / 腫瘍浸潤マクロファージ / 線維化 / α1酸性糖蛋白 / パクリタキセル / エリスロマイシン |
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| Outline of Final Research Achievements |
First, we investigated whether M2 macrophages participate in the development of peritoneal carcinomatosis (PC) in gastric cancer.The number of peritoneal macrophages with the M2 phenotype was significantly higher in gastric cancer patients with PC. the coexistence of MKN45 cells with M2 macrophages resulted in cancer cell proliferation and an acceleration of tumor growth in the xenograft model.
Second, increased concentrations of α1-acid glycoprotein (AGP), an important drug-binding protein, have been reported in the plasma and ascites of cancer patients. This study sought to clarify whether AGP binds to PTX and alters its anticancer effects. AGP > 400 μg/mL significantly suppressed the cell growth inhibitory effect of PTX in vitro, but the co-administration of EM restored it. Elevated AGP concentrations were observed in the ascites of PC model mice. Administration of PTX alone did not markedly diminish PC, whereas co-administration of PTX and EM significantly reduced PC.
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| Free Research Field |
胃十二指腸外科学
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